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Merck’s Molnupiravir (EIDD-281) Effective Against SARS-COV-2

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Merck’s Molnupiravir (EIDD-281) Effective Against SARS-COV-2

Molnupiravir is a nucleoside analog. It has shown to be able to cause mutations accumulation and the RNA replication errors during the virus replication in vitro and in mouse models (in-vivo).

Let’s look at the following
What is Molnupiravir?
What is EIDD-281?
What is a nucleoside and a nucleotide?
How is positive mRNA is replicated to a negative sense RNA and back again during the viral replication?
How does EIDD-281 disrupt this process?
Why is it better performing than Remdesivir?
It’s therapeutic dose is non cytotoxic.
Concerns about its toxicity in humans.


References
https://stm.sciencemag.org/content/12/541/eabb5883
https://en.wikipedia.org/wiki/Molnupiravir
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848974/
https://en.wikipedia.org/wiki/Nucleoside
https://en.wikipedia.org/wiki/Nucleotide
https://www.reuters.com/article/us-health-coronavirus-merck-co/merck-says-study-shows-covid-19-drug-causes-quick-reduction-in-virus-idUSKBN2AY07U
https://clinicaltrials.gov/ct2/show/NCT04405739

 

Merck has a new drug molecule for SARS-COV-2. It is named Molnupiravir or EIDD-2801. We will discuss the following topics about this drug.

 

  1. Need for this anti-viral drug to be used with Remdesivir.
  2. History of the EIDD-2801.
  3. Trial for phase II and phase III.
  4. Route of administration.
  5. Drug properties.
  6. Mechanism of action.
  7. Results in mouse studies.
  8. Therapeutic index.

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